Methyl chloroformate → Carbonic acid, 2-bromo-4-fluorophenyl methyl ester

HRID 48491

반응식

HRID 48491 반응식
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[OH:9].Cl[C:11]([O:13][CH3:14])=[O:12].[OH-].[Na+]>O>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[O:9][C:11]([O:13][CH3:14])=[O:12]

참가 물질

5

반응물 3

HCID 6586Methyl chloroformateHCID 14798Sodium HydroxideHCID 6054722-Bromo-4-fluorophenol

생성물 1

HCID 13268177Carbonic acid, 2-bromo-4-fluorophenyl methyl ester수율 91.8%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

First, 93 g (0.49 mol) of 2-bromo-4-fluorophenol was suspended in 200 ml of water, into which 55 g (0.59 mol) of methyl chloroformate and a solution of 21.5 g (0.51 mol) of sodium hydroxide in 60 ml of water were poured together at 10° C. or lower, and the mixture was stirred at the same temperature for 2 hours. The precipitated crystals were collected by filtration, washed with water, and dried in a vacuum oven, which afforded 111.6 g (0.45 mol) of methyl 2-bromo-4-fluorophenoxyformate.

후처리

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with water
  3. customdried in a vacuum oven, which

출처 및 근거

ORD 기록
ord-3e2b274c706d443391cef1a7a4c9a8b4
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703503B2

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