Ammonia → HCID 86740236, 화합물

HRID 484932

반응식

HRID 484932 반응식
[C:1]([O:5][C:6]([N:8]([CH3:14])[C@@H:9]([C:11]([OH:13])=O)[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][NH2:25])=[CH:18][CH:17]=1.FC1C=CC(C=O)=CC=1.C(CC(O)=O)#N.C(#N)C=C.[NH3:45]>N1CCCCC1.[Ni].N1C=CC=CC=1>[N:45]#[N:8].[C:1]([O:5][C:6]([N:8]([CH3:14])[C@@H:9]([C:11]([NH:25][CH2:24][CH2:23][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([F:15])=[CH:21][CH:20]=1)=[O:13])[CH3:10])=[O:7])([CH3:2])([CH3:3])[CH3:4]

참가 물질

10

반응물 6

HCID 222AmmoniaHCID 7855AcrylonitrileHCID 9740Cyanoacetic acidHCID 680234-FluorobenzaldehydeHCID 64837963-(4-Fluorophenyl)propan-1-amineHCID 16211306N-(tert-Butoxycarbonyl)-N-methyl-D-alanine

생성물 1

HCID 86740236HCID 86740236, 화합물

시약·촉매·용매 3

HCID 935Nickel촉매HCID 8082Piperidine촉매HCID 1049Pyridine용매

실험 절차

By the method of part A of Example 3 N-(tert-butyloxycarbonyl)-N-methyl-D-alanine (2.03 g.) was condensed with 3-(4-fluorophenyl)propylamine (prepared by condensing 4-fluorobenzaldehyde with cyanoacetic acid in refluxing pyridine using piperidine as catalyst and hydrogenating the resulting β-4-fluorophenyl)acrylonitrile in ethanolic ammonia under high pressure using Raney nickel catalyst, m.r. of methanesulfonate salt 129°-131° C.; 2.49 g.), affording N2 -(tert-butyloxycarbonyl)-N2 -methyl-N-[3-(4-fluorophenyl)propyl]-D-alaninamide as a syrup (2.77g.).

출처 및 근거

ORD 기록
ord-be8bde5b5f6d4b3ba46a30ad194ce7b8
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533655

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