Phosphorus oxychloride → Ethyl 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetate
반응식
[F:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([NH:8][CH:9]([C:16](=[O:21])[CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>CN(C)C=O>[F:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]2[O:21][C:16]([CH2:17][CH:18]([CH3:20])[CH3:19])=[C:9]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:8]=2)=[CH:4][CH:3]=1참가 물질
4
실험 절차
3.5 g of ethyl 3-(4-fluorobenzoylamino)-3-isovalerylpropionate, 20 ml of dimethylformamide and 4.1 g of phosphorus oxychloride are treated in the same manner as described in Example 1. 2.5 g of ethyl 2-[2-(4-fluorophenyl)-5-isobutyl-4-oxazolyl]acetate are thereby obtained. Yield: 75.5%.
출처 및 근거
- ORD 기록
- ord-9f47ac5ce1ff4bc1b463cffb3f300a9f
- 출처 데이터셋
- uspto-grants-1985_08
- 특허 번호
- US04535089
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