Benzoyl chloride → N-(3-Methyl-2-oxobutyl)benzamide

HRID 485019노트

반응식

Cl.[C:2]([CH2:7][NH2:8])(=[O:6])[CH:3]([CH3:5])[CH3:4].C(=O)(O)[O-].[Na+].[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:14]([NH:8][CH2:7][C:2](=[O:6])[CH:3]([CH3:5])[CH3:4])(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

반응물 3

HCID 7412Benzoyl chloride

HCID 516892Sodium Bicarbonate

HCID 134017361-Amino-3-methylbutan-2-one hydrochloride

생성물 1

HCID 13490305N-(3-Methyl-2-oxobutyl)benzamide수율 90.5%

실험 절차

4.5 g of isobutyrylmethylamine hydrochloride, 11 g of sodium bicarbonate and 4.81 g of benzoyl chloride are treated in the same manner as described in Preparation 1-(4). 6.07 g of N-benzoylisobutyrylmethylamine are thereby obtained. Yield: 90.5%.

후처리

customas described in Preparation 1-(4)

출처 및 근거

ORD 기록: ord-46595f3b9bd7476498cdb89e27b7c56d
출처 데이터셋: uspto-grants-1985_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04535089

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