Sodium Hydroxide → Tucaresol

HRID 485164

반응식

HRID 485164 반응식
[CH:1]([C:3]1[C:21]([OH:22])=[CH:20][CH:19]=[CH:18][C:4]=1[O:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][CH:8]=1)=[O:2].[OH-].[Na+]>C(O)C.O>[CH:1]([C:3]1[C:21]([OH:22])=[CH:20][CH:19]=[CH:18][C:4]=1[O:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=1)=[O:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 9861133Ethyl 4-(2-formyl-3-hydroxyphenoxymethyl)benzoate

생성물 1

HCID 55223Tucaresol

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Ethyl 4-(2-formyl-3-hydroxyphenoxymethyl)benzoate (0.6 g. 0.002 M) was suspended in 95% ethanol (5 ml) and 1 N sodium hydroxide solution (5 ml) and stirred at room temperature (2.5 hr). The yellow solution was diluted with water, extracted with ethyl acetate, and acidified with concentrated hydrochloric acid. The precipitated solid was filtered off, washed well with water, and recrystallised from 95% ethanol to give 4-(2-formyl-3-hydroxyphenoxymethyl) benzoic acid, m.p. 239°-240° C. (Found: C. 65.99; H, 4.29. C15H12O5 requires C, 66.17; H, 4.44%).

후처리

  1. extractionextracted with ethyl acetate
  2. filtrationThe precipitated solid was filtered off
  3. washwashed well with water
  4. customrecrystallised from 95% ethanol

출처 및 근거

ORD 기록
ord-ff35f5f0f91c472d83d1af4b07930a86
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04535183

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