Methanol → HCID 131713679, 화합물

HRID 485187노트

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HRID 485187 반응식
[C:1]([NH:9][C@@H:10]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:11](=[O:30])[CH2:12][NH:13][C@H:14]([C:16]([N:18]1[CH2:29][CH2:28][CH2:27][C@H:19]1[C:20]([O:22]C(C)(C)C)=[O:21])=[O:17])[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:38].N1CCC[C@H]1C(O)=O.CO.C(O)CCC.C(O)(=O)C.O>Cl.C(O)(=O)C>[ClH:38].[C:1]([NH:9][C@@H:10]([CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[C:11](=[O:30])[CH2:12][NH:13][C@H:14]([C:16]([N:18]1[CH2:29][CH2:28][CH2:27][C@H:19]1[C:20]([OH:22])=[O:21])=[O:17])[CH3:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 887MethanolHCID 10285808Proline hydrochloride, L-HCID 141273661-[N-[(S)-3-(Benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, 1,1-dimethylethyl esterHCID 22056973Butanol acetic acid water

생성물 1

HCID 131713679HCID 131713679, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매

실험 절차

1-[N-[(S)-3-(Benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, 1,1-dimethylethyl ester (740 mg., 1.46 mmole) is dissolved in a solution of hydrogen chloride in acetic acid (1.5N, 10 ml.) and kept at room temperature for 30 minutes. It is then concentrated, taken into water, filtered and lyophilized to obtain 600 mg. of 1-[N-(S)-3-(benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, monohydrochloride; m.p. 83°-163°; [α]D25 =-109° (c=1.04, methanol). Rf 0.6 (silica gel; butanol/acetic acid/water, 4:1:1).

후처리

  1. concentrationIt is then concentrated
  2. filtrationfiltered
  3. customto obtain 600 mg

출처 및 근거

ORD 기록
ord-244be213176e4281b3c133665b57ae3d
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04535176

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