HCID 13520514, 화합물 → 3-[2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-1H-indol-3-yl]propanoic acid

HRID 485317노트

반응식

HRID 485317 반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[NH:14][C:15]2[C:20]([C:21]=1[CH2:22][CH:23](C(OCC)=O)[C:24]([O:26]CC)=[O:25])=[CH:19][CH:18]=[CH:17][CH:16]=2>Cl>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[C:13]1[NH:14][C:15]2[C:20]([C:21]=1[CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:19][CH:18]=[CH:17][CH:16]=2

참가 물질

3

반응물 1

HCID 13520514HCID 13520514, 화합물

생성물 1

HCID 135205153-[2-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)-1H-indol-3-yl]propanoic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 22.8 g (0.05 mole) of [[2-(5-methyl-3-phenyl-4-isoxazolyl)-1H-indol-3-yl]methyl]propanedioic acid, diethyl ester and 150 ml of 12N hydrochloric acid is refluxed for 65 hours. The mixture is cooled and extracted with ether. The ether is washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated. The solid residue is then decolorized with charcoal and recrystallized from ether hexane to give 2-(5-methyl-3-phenyl-4-isoxazolyl)-3-indole propionic acid m.p. 170° to 172° C.

후처리

  1. temperatureis refluxed for 65 hours
  2. temperatureThe mixture is cooled
  3. extractionextracted with ether
  4. washThe ether is washed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. customevaporated
  8. customrecrystallized from ether hexane

출처 및 근거

ORD 기록
ord-438bda3af5374adcac9996d908b9c729
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536499

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