3-[2-(ethoxycarbonyl)ethyl]-N-(3-pyridyl)indole → 3-(2-carboxyethyl)-N-(3-pyridyl)indole

HRID 485338노트

반응식

HRID 485338 반응식
C([O:3][C:4]([CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)=[O:5])C>CO.[OH-].[Na+]>[C:4]([CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)([OH:5])=[O:3]

참가 물질

4

반응물 1

HCID 202701823-[2-(ethoxycarbonyl)ethyl]-N-(3-pyridyl)indole

생성물 1

HCID 134903533-(2-carboxyethyl)-N-(3-pyridyl)indole

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 2.0 g of 3-[2-(ethoxycarbonyl)ethyl]-N-(3-pyridyl)indole in 10 ml of methanol and 10 ml of 1N sodium hydroxide is refluxed for two hours, cooled, and evaporated. The residue is taken up in 10 ml of water, extracted with 10 ml of ether and adjusted to pH=6 with concentrated sulfuric acid. The resulting solid is filtered and dried to yield 3-(2-carboxyethyl)-N-(3-pyridyl)indole, m.p. 147°-149°.

후처리

  1. temperaturecooled
  2. customevaporated
  3. extractionextracted with 10 ml of ether
  4. filtrationThe resulting solid is filtered
  5. customdried

출처 및 근거

ORD 기록
ord-ee34d8fe9f954488bb4d46a25f795861
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536505

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