Sodium Hydroxide → 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole

HRID 485348노트

반응식

HRID 485348 반응식
C([O:3][C:4]([C:6]([CH3:23])=[CH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)=[O:5])C.[OH-].[Na+]>CO.O>[C:4]([C:6]([CH3:23])=[CH:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([C:17]2[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=2)[CH:9]=1)([OH:5])=[O:3]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 539181563-[2-(ethoxycarbonyl)prop-1-enyl]-N-(3-pyridyl)indole

생성물 1

HCID 545426033-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of 1.1 g of 3-[2-(ethoxycarbonyl)-prop-1-enyl)-N-(3-pyridyl)indole, and 0.288 g of sodium hydroxide in 10 ml of methanol and 10 ml of water is heated under reflux for 2 hours, cooled and evaporated. The resulting oil is redissolved in 10 ml of ice water and is neutralized with 0.59 ml of concentrated hydrochloric acid. The resulting solid is filtered and dried to yield 3-(2carboxyprop-1-enyl)-N-(3-pyridyl)indole, m.p. 213°-215°.

후처리

  1. temperatureunder reflux for 2 hours
  2. temperaturecooled
  3. customevaporated
  4. dissolutionThe resulting oil is redissolved in 10 ml of ice water
  5. filtrationThe resulting solid is filtered
  6. customdried

출처 및 근거

ORD 기록
ord-7fda04becbe44a579bd74c36533edeea
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536505

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