Formaldehyde → 4-[3-(1-Piperidinylmethyl)phenoxy]butanal

HRID 485376

반응식

HRID 485376 반응식
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[O:11][CH2:12][CH2:13][CH2:14][CH:15]=NNC(N)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C=O.C(=O)([O-])[O-:27].[Na+].[Na+]>Cl.O>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[O:11][CH2:12][CH2:13][CH2:14][CH:15]=[O:27])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 10340Sodium CarbonateHCID 540828474-[3-(1-Piperidinylmethyl)phenoxy]butanal semicarbazone

생성물 1

HCID 212975474-[3-(1-Piperidinylmethyl)phenoxy]butanal

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

4-[3-(1-piperidinylmethyl)phenoxy]butanal semicarbazone (9.43 g) and 37% formaldehyde (80 ml) in 2N hydrochloric acid (80 ml) were stirred at room temperature for 2.5 h and then diluted with water. The solution was basified with sodium carbonate and extracted with ether. The organic extract was washed with brine, and distilled to give the title compound as a colourless oil (5.59 g) b.p. 200°, 0.06 mm; tlc methanol Rf 0.7.

후처리

  1. extractionextracted with ether
  2. extractionThe organic extract
  3. washwas washed with brine
  4. distillationdistilled

출처 및 근거

ORD 기록
ord-838e4ec62b9849b5a1de5c6fa6cb6f77
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04536508

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