1,1,1,2,3,3,3-Heptafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)propane → (CF3)2Cfocf2chf2

HRID 48543

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HRID 48543 반응식
[C:1]([O:11][C:12]([C:15](I)([F:17])[F:16])([F:14])[F:13])([C:7]([F:10])([F:9])[F:8])([C:3]([F:6])([F:5])[F:4])[F:2]>C(O)(C)C.Cl[Hg]Cl>[C:1]([O:11][C:12]([CH:15]([F:17])[F:16])([F:13])[F:14])([C:7]([F:8])([F:10])[F:9])([C:3]([F:6])([F:5])[F:4])[F:2]

참가 물질

4

반응물 1

HCID 27751861,1,1,2,3,3,3-Heptafluoro-2-(1,1,2,2-tetrafluoro-2-iodoethoxy)propane

생성물 1

HCID 12663045(CF3)2Cfocf2chf2수율 80%

시약·촉매·용매 2

HCID 24085Mercuric Chloride촉매HCID 3776Isopropanol용매2회

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온도
55 °C

실험 절차

A solution of (CF3)2CFOCF2CF2I (21.3 g) in isopropanol (8 mL) was added dropwise to a suspension of Al chips (1 g) and HgCl2 (0.4 g) in isopropanol (30 mL). After the exothermic reaction was completed, the reaction mixture was stirred for 1 hour at 55° C. The reaction mixture was then distilled and a fraction with a b.p. of less then 80° C. was collected. This fraction was washed with an aqueous HCl solution and then distilled over conc. H2SO4 to give (CF3)2CFOCF2CHF2 (11.8 g, 80% yield), b.p. 44 to 46° C. The 1H and 19F NMR were in accord with the assigned structure:

후처리

  1. customAfter the exothermic reaction
  2. distillationThe reaction mixture was then distilled
  3. customof less then 80° C. was collected
  4. washThis fraction was washed with an aqueous HCl solution
  5. distillationdistilled over conc. H2SO4

출처 및 근거

ORD 기록
ord-83f8d50e146b4a3ebdf0a609467648ec
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703533B1

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