HCID 20239805, 화합물 → HCID 13281197, 화합물

HRID 485803노트

반응식

HRID 485803 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[CH:3][CH:2]=1>C(O)C.[Ni]>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[NH:12][CH:11]=[CH:10][N:9]=2)=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 20239805HCID 20239805, 화합물

생성물 1

HCID 13281197HCID 13281197, 화합물수율 62.9%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

반응 조건

온도
210 °C

실험 절차

The mixture of 2-(4-pyridylmethyl)-imidazoline (6.6 g, 0.04M) and Raney-Nickle (3 g) was heated initially at 210° C. and gradually raised to 250° C. in 15 min. After the reaction, the reaction was dissolved in ethanol (50 ml) and filtered to remove the catalyst. The filtrate was stripped to dryness and distilled (0.25 mmHg, 180° C.) to give 2-(4-pyridylmethyl)-imidazole (4.1 g, 62% yield).

후처리

  1. temperaturegradually raised to 250° C. in 15 min
  2. customAfter the reaction
  3. filtrationfiltered
  4. customto remove the catalyst
  5. distillationdistilled (0.25 mmHg, 180° C.)

출처 및 근거

ORD 기록
ord-f276b56b55574833897326deeafc4cb3
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04537969

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