Water → 2-(6-Methoxynaphthalen-2-yl)propanenitrile

HRID 485979

반응식

HRID 485979 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([NH2:16])=O)[CH:7]=[CH:6]2.FC(F)(F)C(OC(=O)C(F)(F)F)=O.O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([CH:13]([CH3:17])[C:14]#[N:16])[CH:7]=[CH:6]2

참가 물질

5

반응물 3

HCID 962WaterHCID 9845Trifluoroacetic anhydrideHCID 6040272-(6-Methoxy-2-naphthyl)propanamide

생성물 1

HCID 6073442-(6-Methoxynaphthalen-2-yl)propanenitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In 50 ml of dry THF, were suspended 3.0 g of oa (6-methoxy-2-naphthyl)-propanamide, followed by adding thereto 8.3 g of trifluoroacetic anhydride and then stirring at room temperature for 12 hours. The resulting reaction mixture was poured into 200 ml of iced water, and then precipitated white solid was filtered off. After purifying with silica gel column, the product was recrystallized twice with ethanol to obtain 2.1 g of oa (6-methoxy-2-naphthyl)propanonitrile (Compound No. 1-1) of this invention.

후처리

  1. additionby adding
  2. customThe resulting reaction mixture
  3. customprecipitated white solid
  4. filtrationwas filtered off
  5. customAfter purifying with silica gel column
  6. customthe product was recrystallized twice with ethanol

출처 및 근거

ORD 기록
ord-177fe75a398b49d0b22efabee0342176
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290478

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