Oxalic Acid → HCID 178526031, 화합물

HRID 486053

반응식

HRID 486053 반응식
[CH2:1]([N:9]=[C:10]=[S:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH:12]1[CH:16]=[C:15]([CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[N:14]=[CH:13]1.[C:23]([OH:28])(=[O:27])[C:24]([OH:26])=[O:25]>C1(C)C=CC=CC=1.C(O)(C)C>[C:23]([OH:28])(=[O:27])[C:24]([OH:26])=[O:25].[CH2:1]([NH:9][C:10]([N:20]1[CH2:19][CH2:18][CH:17]([C:15]2[N:14]=[CH:13][NH:12][CH:16]=2)[CH2:22][CH2:21]1)=[S:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

6

반응물 3

HCID 971Oxalic AcidHCID 16741Phenethyl IsothiocyanateHCID 1784208734-(1H-imidazol-4-yl)piperidine

생성물 1

HCID 178526031HCID 178526031, 화합물

시약·촉매·용매 2

HCID 1140Toluene용매HCID 3776Isopropanol용매

반응 조건

온도
80 °C

실험 절차

A solution of 1.63 g (0.01 mol) of phenethyl isothiocyanate in 60 ml of toluene and 1.51 g (0.01 mol) of 4-(4-imidazolyl)piperidine is heated to reflux for 1h 30 min. After cooling, the solution is evaporated under reduced pressure and the residual oil obtained is dissolved in 60 ml of isopropanol in the presence of 1.2 equivalents of oxalic acid. After 30 minutes of heating at 80° C., the white precipitate formed is drained, washed with ether and recrystallised in acetonitrile.

후처리

  1. temperatureAfter cooling
  2. customthe solution is evaporated under reduced pressure
  3. customthe residual oil obtained
  4. customthe white precipitate formed
  5. washwashed with ether
  6. customrecrystallised in acetonitrile

출처 및 근거

ORD 기록
ord-474f4c34d56c412e9d2b44ede976dcb9
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290790

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