Cyclopropylamine → HCID 178418304, 화합물

HRID 486258

반응식

HRID 486258 반응식
[CH3:1][C:2]1[C:19]([F:20])=[C:18]([F:21])[CH:17]=[C:16]([F:22])[C:3]=1[C:4]([C:6](=[CH:12]OCC)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[CH:23]1([NH2:26])[CH2:25][CH2:24]1>C(O)C>[CH3:1][C:2]1[C:19]([F:20])=[C:18]([F:21])[CH:17]=[C:16]([F:22])[C:3]=1[C:4]([C:6](=[CH:12][NH:26][CH:23]1[CH2:25][CH2:24]1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

참가 물질

4

반응물 2

HCID 69828CyclopropylamineHCID 54242925Ethyl 2-(2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate

생성물 1

HCID 178418304HCID 178418304, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (3.5 g) is dissolved in ethanol (25 ml) and thereto cyclopropylamine (0.84 ml) is added dropwise under ice-cooling. After stirring at room temperature for 30 minutes, the mixture is concentrated and the residue is purified with column chromatography (silica-gel, dichloromethane: n-hexane =1 : 1) to give ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-cyclopropylaminoacrylate (2.7 g).

후처리

  1. temperaturecooling
  2. concentrationthe mixture is concentrated
  3. customthe residue is purified with column chromatography (silica-gel, dichloromethane: n-hexane =1 : 1)

출처 및 근거

ORD 기록
ord-0ba2144ac4a2481783da45fbc16a8c82
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290934

연결된 노트

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