Hydrochloric Acid → HCID 14651266, 화합물

HRID 486264노트

반응식

HRID 486264 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([CH3:15])[C:9]([F:14])=[C:10]([F:13])[CH:11]=2)[C:6](=[O:16])[C:5]([C:17]([O:19]CC)=[O:18])=[CH:4]1)[CH3:2].Cl>C(O)(=O)C>[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([CH3:15])[C:9]([F:14])=[C:10]([F:13])[CH:11]=2)[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 14651267Ethyl 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

생성물 1

HCID 14651266HCID 14651266, 화합물수율 80.4%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Employing ethyl 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.55 g), conc. hydrochloric acid (1.5 ml) and 90 % acetic acid (6 ml), the procedure of Reference Example 10 is repeated to give 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.40 g), as white crystals, m.p. >300° C.

출처 및 근거

ORD 기록
ord-06ec36ab572249a3afd6f72663ff2d32
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05290934

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