1,3,4-Thiadiazol-2-amine → 2-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[1,3,4]thiadiazol-2-yl-acetamide

HRID 48661

반응식

HRID 48661 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:6][CH:7]1[C:16]2[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[CH:14][C:15]=2[O:17][CH3:18])[CH2:10][CH2:9][NH:8]1.Br[CH2:27][C:28](Br)=[O:29].[NH2:31][C:32]1[S:33][CH:34]=[N:35][N:36]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[CH2:6][CH:7]1[C:16]2[C:11](=[C:12]([O:19][CH3:20])[CH:13]=[CH:14][C:15]=2[O:17][CH3:18])[CH2:10][CH2:9][N:8]1[CH2:27][C:28]([NH:31][C:32]1[S:33][CH:34]=[N:35][N:36]=1)=[O:29]

참가 물질

4

반응물 3

HCID 199091,3,4-Thiadiazol-2-amineHCID 61147Bromoacetyl bromideHCID 227426431-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 227425912-[1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-[1,3,4]thiadiazol-2-yl-acetamide

실험 절차

prepared by reaction of 1-(3,4-Dimethoxy-benzyl)-5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 2-bromoacetyl bromide with 2-amino-1,3,4-thiadiazole

출처 및 근거

ORD 기록
ord-784fe9b2029a4553a0dbbd14cae472c2
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703392B2

연결된 노트

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