Hydrochloric Acid → HCID 19096301, 화합물

HRID 486717노트

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HRID 486717 반응식
[CH2:1]([O:3][C:4]([CH:6]1[CH2:10][CH2:9][CH:8]([C:11]([O:13]CC)=[O:12])[S:7]1)=[O:5])[CH3:2].[OH-].[K+].C(OCC)C.Cl>C(O)C.O>[C:11]([CH:8]1[CH2:9][CH2:10][CH:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[S:7]1)([OH:13])=[O:12]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 14797Potassium HydroxideHCID 14993186HCID 14993186, 화합물

생성물 1

HCID 19096301HCID 19096301, 화합물수율 78%

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

To a solution of 2,5-diethoxycarbonyltetrahydrothiophene (2.4 g) in ethanol (10 ml), potassium hydroxide (0.64 g) dissolved in ethanol (10 ml) was added dropwise and the mixture was stirred for 1 hour at room temperature. To the reaction mixture, diethyl ether and water were added. Aqueous layer was acidified with 2N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo to give 1.6 g (78%) of 2-carboxy-5-ethoxycarbonyltetrahydrothiophene.

후처리

  1. additionwas added dropwise
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with saturated sodium chloride solution
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-6c17c3e197b14e76bff124ed188d0b42
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292767

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