Water → HCID 15170714, 화합물

HRID 486879

반응식

HRID 486879 반응식
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].[C:14](Cl)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.O>CN(C)C=O>[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][S:8][C:14]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 6456Trityl chlorideHCID 656604Bucillamine

생성물 1

HCID 15170714HCID 15170714, 화합물수율 60.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of N-(2-mercapto-2-methylpropionyl)-L-cysteine (11.2 g) in dimethylformamide(50 ml), trityl chloride(16.7 g) was added slowly. The reaction mixture was stirred for 2 hours at room temperature, poured into water and extracted with ethyl acetate. The organic layer was washed with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated in vacuo. The oily residue was purified by a silica gel column chromatography to give 14.2 g(60%) of the titled compound.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water and saturated sodium chloride solution
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe oily residue was purified by a silica gel column chromatography

출처 및 근거

ORD 기록
ord-77763c7cf282419bbad470935c97cf60
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292926

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