Acetic Acid → HCID 15170719, 화합물

HRID 486883

반응식

HRID 486883 반응식
[SH:1][C:2]([CH3:13])([CH3:12])[C:3]([NH:5][C@H:6]([C:9]([OH:11])=[O:10])[CH2:7][SH:8])=[O:4].[C:14](O)(=O)C>CCOCC.[N+](=C)=[N-]>[CH3:14][O:10][C:9](=[O:11])[C@H:6]([CH2:7][SH:8])[NH:5][C:3](=[O:4])[C:2]([SH:1])([CH3:13])[CH3:12]

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 656604Bucillamine

생성물 1

HCID 15170719HCID 15170719, 화합물수율 94%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매2회HCID 9550Diazomethane용매

실험 절차

To a solution of N-(2-mercapto-2-methylpropionyl)-L-cysteine (1.0 g) in ether(3 ml), diazomethane dissolved in ether(12 ml) was added dropwise under ice-cooling. After the addition, acetic acid was added to the reaction mixture. The reaction mixture was washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo. The oily residue was purified by a silica gel column chromatography to give 1.0 g(94%) of the titled compound.

후처리

  1. additionwas added dropwise under ice-
  2. temperaturecooling
  3. additionwas added to the reaction mixture
  4. washThe reaction mixture was washed with saturated sodium hydrogen carbonate solution and saturated sodium chloride solution
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe oily residue was purified by a silica gel column chromatography

출처 및 근거

ORD 기록
ord-d22ad1ba57f24a5b9ffc12e56b23c69d
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05292926

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