Hydrochloric Acid → Amino-5,6-dichloro-3-nitrobenzoic acid

HRID 487195

반응식

HRID 487195 반응식
[N+:1]([C:4]1[C:5](Cl)=[C:6]([C:10]([Cl:14])=[C:11]([Cl:13])[CH:12]=1)[C:7]([OH:9])=[O:8])([O-:3])=[O:2].ClC1C=CC=CC=1C[NH2:20].Cl>C1(C)C=CC=CC=1>[NH2:20][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:12][C:11]([Cl:13])=[C:10]([Cl:14])[C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 666482-ChlorobenzylamineHCID 190942393-Nitro-2,5,6-trichlorobenzoic acid

생성물 1

HCID 131718350Amino-5,6-dichloro-3-nitrobenzoic acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a stirred solution of 3-nitro-2,5,6-trichlorobenzoic acid (37.1 mmol, 10.0 g) in 150 mL of toluene, was added 2-chlorobenzylamine (81.6 mmol, 11.56 g). The reaction mixture was refluxed overnight, poured into dilute hydrochloric acid and vigorously stirred. The resulting solid was filtered. The product was dissolved in toluene and then precipitated with diethyl ether. Recrystallization of the product from methanol gave 3.4 g of 2-[2-chlorophenyl)methyl]amino-5,6-dichloro-3-nitrobenzoic acid; mp 168.5°-171° C.

후처리

  1. temperatureThe reaction mixture was refluxed overnight
  2. filtrationThe resulting solid was filtered
  3. dissolutionThe product was dissolved in toluene
  4. customprecipitated with diethyl ether
  5. customRecrystallization of the product from methanol

출처 및 근거

ORD 기록
ord-2acbb49479fc4ff59a140401e97e8c33
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05294631

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