Dimethyl Sulfoxide → Benzeneethanamine, N-phenyl-

HRID 487585

반응식

HRID 487585 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:8](Br)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+].CS(C)=O>O>[C:10]1([CH2:9][CH2:8][NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 6115AnilineHCID 7666Phenethyl bromideHCID 11430Potassium Carbonate

생성물 1

HCID 74443Benzeneethanamine, N-phenyl-

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of aniline (9.1 ml, 100 mmol), phenethylbromide 18.5 g, 100 mmol), potassiumcarbonate (13.8 g, 100 mmol) and 50 ml dimethylsulfoxide is stirred at ambient temperature for 72 hours, and is diluted with 200 ml water. The mixture is extracted three times with diethylether and the combined organic phases is washed with water and brine and dried over magnesium sulphate. The solution is concentrated in vacuo and the crude product is subjected to a vacuum distillation yielding the title compound as a colourless oil dest. 120°-128° C./0.7 mbar.

후처리

  1. extractionThe mixture is extracted three times with diethylether
  2. washthe combined organic phases is washed with water and brine
  3. dry with materialdried over magnesium sulphate
  4. concentrationThe solution is concentrated in vacuo
  5. distillationthe crude product is subjected to a vacuum distillation

출처 및 근거

ORD 기록
ord-67c4a37d41c44531ba33590a77173983
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05296493

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