Formaldehyde → (1-benzyl-1H-imidazol-2-yl)methanol

HRID 487586

반응식

HRID 487586 반응식
[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]=[O:14].[OH-].[Na+]>>[CH2:1]([N:8]1[CH:12]=[CH:11][N:10]=[C:9]1[CH2:13][OH:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 779181-Benzylimidazole

생성물 1

HCID 311778(1-benzyl-1H-imidazol-2-yl)methanol

실험 절차

A mixture of 1-benzyl-imidazole (5 g, 32 mmol), formaldehyde 37% (10 ml, 134 mmol) and sodium hydroxide (100 mg) is refluxed for 7 days and is extracted with ethylacetate. Concentration in vacuo yields 1-benzyl-2-hydroxymethyl-imidazole.

후처리

  1. temperatureis refluxed for 7 days
  2. extractionis extracted with ethylacetate
  3. concentrationConcentration in vacuo

출처 및 근거

ORD 기록
ord-577345ed1bed493fb40d458419d32569
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05296493

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