4-Tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole → 4-Tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole

HRID 487704노트

반응식

HRID 487704 반응식
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([C:26]([O:28]CC)=[O:27])[C:21]([O:23]CC)=[O:22])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>Cl>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([CH2:19][CH:20]([C:21]([OH:23])=[O:22])[C:26]([OH:28])=[O:27])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 1

HCID 190926974-Tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole

생성물 1

HCID 190927654-Tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole수율 27.7%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 4-tert-butyl-2-[5-(2,2-diethoxycarbonylethyl)benzofuran-2-yl]thiazole (3.99 g) and conc. hydrochloric acid (20 ml) was stirred under reflux for 6 hours. After being cooled, the resulting mixture was extracted with ethyl acetate. The extract was allowed to stand until there were no further precipitates separated out. The precipitates were collected by filtration and washed with ethyl acetate to give 4-tert-butyl-2-[5-(2,2-dicarboxyethyl)benzofuran-2-yl]thiazole (0.96 g).

후처리

  1. temperatureunder reflux for 6 hours
  2. temperatureAfter being cooled
  3. extractionthe resulting mixture was extracted with ethyl acetate
  4. customno further precipitates
  5. customseparated out
  6. filtrationThe precipitates were collected by filtration
  7. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-79e832f0fa3b43a795750c260e9bf939
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05296495

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