1-Chloro-2-(trifluoromethyl)benzene → HCID 532426, 화합물

HRID 487749

반응식

HRID 487749 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17](O)=[CH:16][CH:15]=1.C1(P(C2C=CC=CC=2)CCCCP(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:51](=[O:54])([O-])[O-:52].[Na+].[Na+].[C]=O>[Pd](Cl)Cl>[F:9][C:8]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:51]([O:52][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=1)=[O:54]

참가 물질

7

반응물 5

HCID 69211-Chloro-2-(trifluoromethyl)benzeneHCID 90154-MethoxyphenolHCID 10340Sodium CarbonateHCID 821241,4-Bis(diphenylphosphino)butaneHCID 178418416HCID 178418416, 화합물2회

생성물 1

HCID 532426HCID 532426, 화합물

시약·촉매·용매 1

HCID 24290Palladium Chloride촉매

실험 절차

In an autoclave made of a metal were placed 45.13 g of ortho-chlorobenzotrifluoride, 6.2 g of para-methoxyphenol, 88.5 mg of palladium chloride, 213 mg of 1,4-bisdiphenylphosphinobutane and 5.3 g of sodium carbonate. The air in the autoclave was replaced with carbon monoxide introduced thereinto in several times, after which carbon monoxide was further introduced to adjust its pressure therein to 30 kg/cm2. The internal temperature was adjusted to 190° C. on a salt bath and the reaction was carried out thereon with stirring for 5 hours.

후처리

  1. additionintroduced
  2. customThe internal temperature was adjusted to 190° C. on a salt bath

출처 및 근거

ORD 기록
ord-d55c1ac288e24512823a757050b66de0
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05296601

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