3-Methyl-1-pentanol → Pyridine, 3-(4-methylhexyl)

HRID 487862

반응식

HRID 487862 반응식
[CH2:1]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH3:13]C(CC)CCBr.P(Br)(Br)Br.CC(CC)CCO>CCOCC.N1C=CC=CC=1>[CH3:13][CH:4]([CH2:5][CH3:6])[CH2:3][CH2:2][CH2:1][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1

참가 물질

7

반응물 4

HCID 115083-Methyl-1-pentanolHCID 227663-HexylpyridineHCID 24614Phosphorus tribromideHCID 398991-Bromo-3-methylpentane

생성물 1

HCID 529404Pyridine, 3-(4-methylhexyl)

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 3283Diethyl Ether용매

실험 절차

3-(4-Methylhexyl)pyridine was prepared in a similar manner to that described above with regard to 3-hexylpyridine but using 3-methyl-1-pentylbromide [prepared by adding over 1 h, at -30° C. and under N2, 22.5 g of PBr3 (0.083 mol; 7.8 ml) to a mixture of 21.6 g (0.212 mol) of 3-methyl-1-pentanol, 3.95 g of anhydrous pyridine and 88.4 ml of anhydrous sulfuric ether; the mixture was allowed to react for 1 h at -30° C. and then for 1 night at room temperature; the reaction product was extracted and washed in the usual manner and purified on a Vigreux column to provide 20.8 g of pure product].

후처리

  1. customprepared
  2. additionby adding over 1 h, at -30° C. and under N2
  3. customto react for 1 h at -30° C.
  4. waitfor 1 night at room temperature
  5. extractionthe reaction product was extracted
  6. washwashed in the usual manner
  7. custompurified on a Vigreux column

출처 및 근거

ORD 기록
ord-1734eb148fa443828db0fb93bfafbdac
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298486

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