Sodium Hydroxide → HCID 19091325, 화합물

HRID 487867노트

반응식

HRID 487867 반응식
[OH-].[Na+].C([O:5][C:6](=[O:31])[CH:7]([CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][S:27]([CH3:30])(=[O:29])=[O:28])[CH:21]=1)[NH:8][C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10])C>C1COCC1>[CH2:12]([O:11][C:9]([NH:8][CH:7]([C:6]([OH:31])=[O:5])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([NH:26][S:27]([CH3:30])(=[O:29])=[O:28])[CH:21]=1)=[O:10])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19091322HCID 19091322, 화합물

생성물 1

HCID 19091325HCID 19091325, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Add 1N NaOH (107 mL) to the product of Step A (14.80 g) in THF (100 mL) and stir overnight. Concentrate the THF solution in vacuo and partition between EtOAc (700 mL)/2N HCl (200 mL). Concentrate the dried (MgSO4) EtOAc solution in vacuo to a residue. Add CH2Cl2 (50 mL) and concentrate in vacuo (3 times) to give N-benzyloxycarbonyl-3-methanesulfonamido-D,L-phenylalanine.

후처리

  1. concentrationConcentrate the THF solution in vacuo
  2. custompartition between EtOAc (700 mL)/2N HCl (200 mL)
  3. concentrationConcentrate the
  4. dry with materialdried (MgSO4) EtOAc solution in vacuo to a residue
  5. concentrationAdd CH2Cl2 (50 mL) and concentrate in vacuo (3 times)

출처 및 근거

ORD 기록
ord-6ef29506c8b346bfad1dcdec32b89d06
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298492

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