2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene

HRID 488018

반응식

HRID 488018 반응식
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH3:10][O-:11].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH3:10]

참가 물질

4

반응물 2

HCID 769652-Bromobenzyl bromideHCID 10942334Sodium Methoxide

생성물 1

HCID 129271621-Bromo-2-(methoxymethyl)benzene

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

685 g (2.74 mol) of o-bromobenzyl bromide was refluxed with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. After the mixture had cooled to room temperature it was evaporated down, taken up in ethyl acetate, and washed with water. After the organic phase had been dried over sodium sulfate, it was again evaporated down. There was obtained 478.2 g (87%) of the title substance as a colorless liquid.

후처리

  1. customwas evaporated down
  2. washwashed with water
  3. dry with materialAfter the organic phase had been dried over sodium sulfate, it
  4. customwas again evaporated down
  5. customThere was obtained 478.2 g (87%) of the title substance as a colorless liquid

출처 및 근거

ORD 기록
ord-c3460ea5355a4863a64497f82519f589
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298527

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