Water → (E)-1-[3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine

HRID 488148노트

반응식

HRID 488148 반응식
[CH2:1]([C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([O:25]COC)=[C:6]([O:23][CH3:24])[CH:7]=[C:8]2/[CH:13]=[CH:14]/[C:15]([N:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:16])[CH3:2].O>CC(C)=O.Cl>[CH2:1]([C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5]([OH:25])=[C:6]([O:23][CH3:24])[CH:7]=[C:8]2/[CH:13]=[CH:14]/[C:15]([N:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1)=[O:16])[CH3:2]

참가 물질

5

반응물 2

HCID 962WaterHCID 14986472(E)-1-[3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine

생성물 1

HCID 14986482(E)-1-[3-(5-ethyl-4-hydroxy-3-methoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine수율 89.4%

시약·촉매·용매 2

HCID 180Acetone용매HCID 313Hydrochloric Acid용매

실험 절차

960 mg of (E)-1-[3-(5-ethyl-3-methoxy-4-methoxymethoxy-1-naphthyl)-1-oxo-2-propenyl]piperidine was dissolved in 50 ml of acetone, to which 1 ml of concentrated hydrochloric acid was gradually added at room temperature. After stirring at room temperature for 5 hours, the reaction mixture was slowly poured into water. The resultant crystals were collected by filtration, washed with water and dried to obtain 760 mg of the titled compound as yellow crystals.

후처리

  1. additionwas gradually added at room temperature
  2. filtrationThe resultant crystals were collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-2b7b0b8b3b4a4007aa8f80804f8e2253
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298649

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