Sodium Hydroxide → 3-Hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoic acid

HRID 488152노트

반응식

HRID 488152 반응식
[OH:1][CH:2]([CH2:8][CH2:9][CH:10]=[C:11]([CH3:23])[CH2:12][CH2:13][CH:14]=[C:15]([CH3:22])[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20])[CH2:3][C:4]([O:6]C)=[O:5].[OH-].[Na+]>C(O)C>[OH:1][CH:2]([CH2:8][CH2:9][CH:10]=[C:11]([CH3:23])[CH2:12][CH2:13][CH:14]=[C:15]([CH3:22])[CH2:16][CH2:17][CH:18]=[C:19]([CH3:21])[CH3:20])[CH2:3][C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 53652710Methyl 3-hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoate

생성물 1

HCID 537523723-Hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of methyl 3-hydroxy-7,11,15-trimethylhexadeca-6,10,14-trienoate (139 mg, 430 μmol), ethanol (1 mL) and sodium hydroxide (1N, 440 μL, 440 μmol) was stirred at room temperature for two hours. The crude mixture was purified by flash chromatography on a 20 mm ID silica gel column. Elution of the column with choloform:acetic acid (40:1/v=v) gave title compound as a colorless gum.

후처리

  1. customThe crude mixture was purified by flash chromatography on a 20 mm ID silica gel column
  2. washElution of the column with choloform

출처 및 근거

ORD 기록
ord-38b575bca1d94ac9b544ec23065db09a
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298655

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