Water → farnesylamine

HRID 488157노트

반응식

HRID 488157 반응식
O.[CH3:2]/[C:3](/[CH2:9][CH2:10]/[CH:11]=[C:12](\[CH3:19])/[CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])=[CH:4]\[CH2:5][N:6]=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[CH3:2]/[C:3](/[CH2:9][CH2:10]/[CH:11]=[C:12](\[CH3:19])/[CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])=[CH:4]\[CH2:5][NH2:6]

참가 물질

5

반응물 3

HCID 962Water2회HCID 11776TriphenylphosphineHCID 10014874HCID 10014874, 화합물

생성물 1

HCID 6449783farnesylamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Water (46 μL) was added to a stirred mixture of (E,E)-3,7,11-trimethyl-2,6,10-dodecatrienylazide (0.8 g, 3.2 mmol) and triphenylphosphine (0.94 g, 3.62 mmol) in THF (3 mL) and stirred at room temperature overnight. An additional amount of water (46 ML) was added and stirred for another two hours. The reaction mixture was evaporated to dryness and the residue was redissolved in methylene chloride, then MgSO4 was added and filtered. The filtrate was concentrated in vacuo to give the crude title compound as an oily solid which was used in the next step without purification.

후처리

  1. stirringstirred for another two hours
  2. customThe reaction mixture was evaporated to dryness
  3. dissolutionthe residue was redissolved in methylene chloride
  4. additionMgSO4 was added
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-d0a60b80fcd24b76a175e444d58de7ed
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298655

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