Sodium Hydroxide → N-(carboxymethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine

HRID 488316노트

반응식

HRID 488316 반응식
[OH-].[Na+].C([O:5][C:6](=[O:42])[CH2:7][N:8]([CH2:36][C:37]([O:39]CC)=[O:38])[C:9](=[O:35])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:13]=[CH:12][C:11]=1[O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)C>>[C:37]([CH2:36][N:8]([C:9](=[O:35])[C:10]1[CH:15]=[C:14]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:13]=[CH:12][C:11]=1[O:27][CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[CH2:7][C:6]([OH:42])=[O:5])([OH:39])=[O:38]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 19091876N-(2-ethoxy-2-oxoethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine ethyl ester

생성물 1

HCID 19091776N-(carboxymethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine수율 94%

실험 절차

Sodium hydroxide hydrolysis of N-(2-ethoxy-2-oxoethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine ethyl ester under conditions described in Example 81 gave N-(carboxymethyl)-N-[5-(decyloxy)-2-(phenylmethoxy)benzoyl]glycine (94% yield, mp 74°-78°).

출처 및 근거

ORD 기록
ord-9e16c53460e647da80258ffb231ab7f3
출처 데이터셋
uspto-grants-1994_03
특허 번호
US05298652

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