Hydrochloric Acid → Ethyl 6-(methylamino)-3-pyridazinecarboxylate

HRID 488461노트

반응식

HRID 488461 반응식
[CH3:1][NH:2][C:3]1[N:4]=[N:5][C:6]([C:9]([OH:11])=[O:10])=[CH:7][CH:8]=1.Cl.[CH2:13](O)[CH3:14]>>[CH3:1][NH:2][C:3]1[N:4]=[N:5][C:6]([C:9]([O:11][CH2:13][CH3:14])=[O:10])=[CH:7][CH:8]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 222714356-(Methylamino)pyridazine-3-carboxylic Acid

생성물 1

HCID 22271465Ethyl 6-(methylamino)-3-pyridazinecarboxylate

실험 절차

A solution of 3-methylaminopyridazine-6-carboxylic acid (0.58 g) in ethanol (50 ml) was saturated with HCl gas, refluxed 48 hours and evaporated. The residue was partitioned between EtOAc and aqueous NaHCO3, separated and the aqueous re-extracted with EtOAc. The organic was dried and evaporated to give title compound (0.61 g). MS(+ve ion chemical ionisation) m/z 182 (MH+, 100%).

후처리

  1. temperaturerefluxed 48 hours
  2. customevaporated
  3. customThe residue was partitioned between EtOAc and aqueous NaHCO3
  4. customseparated
  5. extractionthe aqueous re-extracted with EtOAc
  6. customThe organic was dried
  7. customevaporated

출처 및 근거

ORD 기록
ord-a04624f73001438ab890b608c3aae5d7
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972297B2

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