2-Chlorobenzoic Acid → 2-{4-[2-(4-Dibutylamino-phenyl)-ethyl]phenylamino}-benzoic acid

HRID 488492노트

반응식

HRID 488492 반응식
Cl[C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(N[C:16]1([NH:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)=[CH:18][CH2:17]1)CCC.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.[Cu].[Cu]Cl>[CH2:10]([N:31]([CH2:32][CH2:33][CH2:34][CH3:35])[C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][C:24]2[CH:25]=[CH:26][C:27]([NH:30][C:2]3[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=3[C:4]([OH:6])=[O:5])=[CH:28][CH:29]=2)=[CH:20][CH:21]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

7

반응물 3

HCID 83742-Chlorobenzoic AcidHCID 11430Potassium CarbonateHCID 86594891HCID 86594891, 화합물

생성물 1

HCID 222696822-{4-[2-(4-Dibutylamino-phenyl)-ethyl]phenylamino}-benzoic acid수율 18.6%

시약·촉매·용매 3

HCID 23978Copper촉매HCID 62652Cuprous chloride촉매HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared from 2-chlorobenzoic acid (1.46 g, 9.36 mmol), 4-[2-(4,4-dibutylaminophenyl)ethyl]phenylamine (3.31 g, 10.20 mmol), anhydrous potassium carbonate (4.27 g, 30.88 mmol), copper powder (1.25 g, 19.65 mmol), and copper(I) chloride (0.092 g, 0.93 mmol) in dry DMF (30 mL) using the procedure described in Example 1, Step C, Method B. This procedure yielded a 0.39 g (0.87 mmol, 8.6%) of the desired product. mp 115-117° C.

출처 및 근거

ORD 기록
ord-e0761f2215a5472dac2c64bded80ab9e
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972287B1

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