2-Chlorobenzoic Acid → 2-{4-[4-(3,4-Dichlorophenyl)butyl]phenylamino}benzoic acid

HRID 488506노트

반응식

HRID 488506 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([OH:25])=[O:24].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.[Cu].[Cu]Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([NH:19][C:21]3[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=3[C:23]([OH:25])=[O:24])=[CH:17][CH:18]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

7

반응물 3

HCID 83742-Chlorobenzoic AcidHCID 11430Potassium CarbonateHCID 136560814-[4-(3,4-Dichlorophenyl)butyl]phenylamine

생성물 1

HCID 98664532-{4-[4-(3,4-Dichlorophenyl)butyl]phenylamino}benzoic acid

시약·촉매·용매 3

HCID 23978Copper촉매HCID 62652Cuprous chloride촉매HCID 6228Dimethylformamide용매

실험 절차

The title compound, mp 98-105° C., was prepared from 4-[4-(3,4-dichlorophenyl)butyl]phenylamine (0.50 g, 1.7 mmol), 2-chlorobenzoic acid (0.24 g, 1.56 mmol), anhydrous potassium carbonate (0.71 g, 5.15 mmol), copper powder (0.21 g, 3.28 mmol), and copper(I) chloride (0.015 g, 0.15 mmol) in dry DMF (5 mL) using the procedure described in Example 1, Step C, Method B.

출처 및 근거

ORD 기록
ord-c7238bc1bb924fc29a8d4a27c5bdfef6
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972287B1

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