Sodium Hydroxide → 2-{4-[5-(3,4-Dichlorophenyl)pentyl]phenylamino}4-methoxy-5-nitrobenzoic acid

HRID 488513노트

반응식

HRID 488513 반응식
C[O:2][C:3](=[O:35])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([O:13][CH3:14])=[CH:6][C:5]=1[NH:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([Cl:33])=[C:29]([Cl:34])[CH:28]=2)=[CH:18][CH:17]=1.[OH-].[Na+]>C1COCC1>[Cl:34][C:29]1[CH:28]=[C:27]([CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][C:19]2[CH:20]=[CH:21][C:16]([NH:15][C:5]3[CH:6]=[C:7]([O:13][CH3:14])[C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=3[C:3]([OH:35])=[O:2])=[CH:17][CH:18]=2)[CH:32]=[CH:31][C:30]=1[Cl:33]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 540571152-{4-[5-(3,4-Dichlorophenyl)-pentyl]phenylamino}4-methoxy-5-nitrobenzoic acid methyl ester

생성물 1

HCID 222698172-{4-[5-(3,4-Dichlorophenyl)pentyl]phenylamino}4-methoxy-5-nitrobenzoic acid수율 42.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The title compound was prepared from 2-{4-[5-(3,4-dichlorophenyl)-pentyl]phenylamino}-4-methoxy-5-nitrobenzoic acid methyl ester (145 mg, 0.28 mmol) and 1N NaOH (aq.) (0.56 mL) in THF (1.2 mL) using the procedure described in Example 2. Purification by flash chromatography (silica gel, 10% MeOH/CH2Cl2), then recrystallization with MeOH yielded 58 mg (0.12 mmol, 41%) of the desired product. mp 192-193° C.

후처리

  1. customPurification by flash chromatography (silica gel, 10% MeOH/CH2Cl2)
  2. customrecrystallization with MeOH

출처 및 근거

ORD 기록
ord-563f1884a2da435085ac25301f0f9100
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972287B1

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