Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate → Trifluoroacetic acid

HRID 488658

반응식

HRID 488658 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[C:15]=1[C:16]([O:18][CH3:19])=[O:17])=O)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].ClCCl>>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:23]=[CH:22][CH:21]=[C:20]([OH:24])[C:15]=1[C:16]([O:18][CH3:19])=[O:17].[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]

참가 물질

4

반응물 2

HCID 10980693Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoateHCID 21863450Trifluoroacetic acid methylene chloride

생성물 2

HCID 6422Trifluoroacetic acidHCID 11832643Methyl 2-(4-aminobutoxy)-6-hydroxybenzoate

실험 절차

Methyl 2-{4-[(tert-butoxycarbonyl)amino]butoxy}-6-hydroxybenzoate (410 mg, 1.2 mmol) was treated with trifluoroacetic acid/dichloromethane (6 mL, 1:1/v:v) at ambient temperature for 3 hours, concentrated under reduced pressure and evaporated with acetonitrile twice to provide the titled amine as its trifluoroacetic acid salt (450 mg).

후처리

  1. concentrationconcentrated under reduced pressure
  2. customevaporated with acetonitrile twice

출처 및 근거

ORD 기록
ord-568236dc42d244379cbec0ebfbe7e366
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972340B2

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