Hydrochloric Acid → Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoate

HRID 488682

반응식

HRID 488682 반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[C:15]([C:28]([O:30][CH3:31])=[O:29])=[C:16]([O:24]COC)[C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2)=O)(C)(C)C.Cl>O1CCOCC1>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[C:15]([C:28]([O:30][CH3:31])=[O:29])=[C:16]([OH:24])[C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22271972Methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoate

생성물 1

HCID 22271969Methyl 3-(4-aminobutoxy)-1-hydroxy-2-naphthoate수율 102.6%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a mixture of methyl 3-{4-[(tert-butoxycarbonyl)amino]butoxy}-1-(methoxymethoxy)-2-naphthoate (28 mg, 0.064 mmol) was added 4M HCl in dioxane (1 mL). The mixture was stirred at ambient temperature for 30 minutes, concentrated under reduced pressure to provide the titled compound (19 mg, 100%) as its hydrochloride salt.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5eae51615e85413895203e397774bdcf
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06972340B2

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