Hydrochloric Acid → Sibutramine Hydrochloride

HRID 488806노트

반응식

HRID 488806 반응식
[CH3:1][CH:2]([CH2:4][CH:5]([N:17]([CH3:19])[CH3:18])[C:6]1([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:3].[ClH:20]>CC(OC)(C)C.C(OCC)C>[CH3:3][CH:2]([CH2:4][CH:5]([N:17]([CH3:18])[CH3:19])[C:6]1([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[CH2:7][CH2:8][CH2:9]1)[CH3:1].[ClH:20]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 5210Sibutramine

생성물 1

HCID 64764Sibutramine Hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 15413tert-Butyl methyl ether용매

실험 절차

Sibutramine free base (2.25 g) was dissolved in MTBE (20 mL) and that solution was added to 20 mL 1M HCl in diethyl ether. The reaction mixture was stirred for 30 minutes, and the solid was collected by filtration to give 1.73 g after drying. The product was characterized by 1H NMR.

후처리

  1. filtrationthe solid was collected by filtration
  2. customto give 1.73 g
  3. customafter drying

출처 및 근거

ORD 기록
ord-d96744356372492eb5d19ad922e8ba89
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06974838B2

반응 노트

불러오는 중…