Hydrogen Bromide → HCID 178510513, 화합물

HRID 488925노트

반응식

HRID 488925 반응식
Cl[C:2]1[N:9]=[CH:8][CH:7]=[C:6]([O:10]C)[C:3]=1[C:4]#[N:5].[BrH:12]>C(O)(=O)C>[Br:12][C:2]1[N:9]=[CH:8][CH:7]=[C:6]([OH:10])[C:3]=1[C:4]#[N:5]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 14709302-Chloro-4-methoxynicotinonitrile

생성물 1

HCID 178510513HCID 178510513, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

2-Chloro-4-methoxy-nicotinonitrile (M. Mittelbach et al., Arch. Pharm. (Weinheim Ger.), 1985, GE, 318, 6, 481-486) (6.92 g) was suspended in 70 mL of 30% HBr in acetic acid in a pressure vessel and heated with stirring at 100° C. for 2 h. The reaction was cooled to room temperature and filtered, washing well with H2O, and dried in vacuo overnight at 50° C. providing 4.85 g 2-bromo-4-hydroxy-nicotinonitrile as a white solid. Proton NMR(DMSO) indicated the product was a mixture of 69% bromo compound with 31% starting chloro analog.

후처리

  1. temperatureheated
  2. temperatureThe reaction was cooled to room temperature
  3. filtrationfiltered
  4. washwashing well with H2O
  5. customdried in vacuo overnight at 50° C.

출처 및 근거

ORD 기록
ord-a4d0ecec7dc743648ae7d382a7247cbf
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06974870B2

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