Methyl iodide → 1-Methyl-3-[3-(1-methylpyrrol-2-yl)-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil

HRID 48963노트

반응식

HRID 48963 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[C:11]2[CH:12]=[C:13]([N:16]3[C:21](=[O:22])[CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[NH:18][C:17]3=[O:27])[CH:14]=[CH:15][C:10]=2[S:9][N:8]=1.[C:28](=O)([O-])[O-].[K+].[K+].IC>CN(C)C=O>[CH3:28][N:18]1[C:19]([C:23]([F:26])([F:25])[F:24])=[CH:20][C:21](=[O:22])[N:16]([C:13]2[CH:14]=[CH:15][C:10]3[S:9][N:8]=[C:7]([C:3]4[N:2]([CH3:1])[CH:6]=[CH:5][CH:4]=4)[C:11]=3[CH:12]=2)[C:17]1=[O:27]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 206342623-[3-(1-Methylpyrrol-2-yl)-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil

생성물 1

HCID 206341671-Methyl-3-[3-(1-methylpyrrol-2-yl)-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil수율 21.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of 3-[3-(1-methylpyrrol-2-yl)-1,2-benzisothiazol-5-yl]-6-(trifluoromethyl)uracil(1.35 g, 3.44 mmol), dry dimethylformamide and potassium carbonate (0.710 g, 5.14 mmol) is added iodomethane (0.730 g, 5.14 mmol). The resultant mixture is stirred overnight at room temperature and poured into ice water. Filtration and drying affords the title compound as a pink foam (0.300 g, 21.4%) which is identified by NMR spectral analysis.

후처리

  1. filtrationFiltration
  2. customdrying

출처 및 근거

ORD 기록
ord-860be216401c4b5da222ad4032ef4170
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706663B2

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