Hydrochloric Acid → 3-Ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

HRID 4897

반응식

HRID 4897 반응식
C(O[C:4]([C:6]1[N:10]=[C:9]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[Cl:20])[O:8][N:7]=1)=[O:5])C.[CH2:21]([Mg]Br)[CH3:22].Cl>O1CCCC1>[CH2:21]([C:4]([C:6]1[N:10]=[C:9]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[Cl:20])[O:8][N:7]=1)=[O:5])[CH3:22]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 197971323-Ethoxycarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazoleHCID 178418443HCID 178418443, 화합물

생성물 1

HCID 197971233-Ethylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole수율 83%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
-78 °C

실험 절차

0.95 g of 3-ethoxycarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole was added to 30 ml of tetrahydrofuran. The mixture was cooled to -78° C., and then 3 ml of ethylmagnesium bromide (2M solution) was added dropwise. After the mixture was stirred at -78° C. for 1 hour, it was poured into cold aqueous 5% HCl solution. After the resulted product was extracted with ether and concentrated, it was purified by column chromatography(hexane:ethylacetate=4:1) to obtain 0.75 g of the desired product(yield: 83.0%).

후처리

  1. extractionAfter the resulted product was extracted with ether
  2. concentrationconcentrated
  3. customit was purified by column chromatography(hexane:ethylacetate=4:1)

출처 및 근거

ORD 기록
ord-e5bfa70b33c24bb5b62e1dfb336704c5
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242890

연결된 노트

불러오는 중…