Ethanethioic acid, S-(2-(((2R)-2-(acetylamino)-3-mercapto-1-oxopropyl)amino)ethyl)ester → HCID 516557, 화합물

HRID 489876노트

반응식

HRID 489876 반응식
[C:1]([NH:4][C@H:5]([C:27]([NH:29][CH2:30][CH2:31][S:32][C:33](=[O:40])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:28])[CH2:6][S:7]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)(=[O:3])[CH3:2].C(N[C@H](C(NCCSC(=O)C)=O)CS)(=O)C.C(Cl)Cl.CO>C(Cl)(Cl)Cl>[C:1]([NH:4][C@H:5]([C:27]([NH:29][CH2:30][CH2:31][S:32][C:33](=[O:40])[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:28])[CH2:6][SH:7])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 484333Ethanethioic acid, S-(2-(((2R)-2-(acetylamino)-3-mercapto-1-oxopropyl)amino)ethyl)esterHCID 11284496HCID 11284496, 화합물HCID 21226129Dichloromethane methanol

생성물 1

HCID 516557HCID 516557, 화합물수율 63%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

This compound is obtained by the S-detritylation of 12 (4.44 mmol). The protocol used is the same as that described in example 1 for the synthesis of I-152. After the various treatments, a gum is collected, which gum is purified by flash chromatography on a silica gel column (eluent: AcOEt/petroleum ether 50%). I-198 is isolated in the form of a white solid with a yield of 63%. Rf CH2Cl2/MeOH, 9.5/0.5): 0.38. M.p.=128-130° C. [α]D20=−24.7° (c 1.01, CHCl3).

후처리

  1. customAfter the various treatments, a gum is collected
  2. customwhich gum is purified by flash chromatography on a silica gel column (eluent: AcOEt/petroleum ether 50%)
  3. customI-198 is isolated in the form of a white solid with a yield of 63%

출처 및 근거

ORD 기록
ord-74b57e04fc1042d18eaeada6d0afee5f
출처 데이터셋
uspto-grants-2005_12
특허 번호
US06979747B2

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