Trifluoroacetic acid → (2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidine trifluoroacetate

HRID 490137

반응식

HRID 490137 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:12]([C@@H:14]2[CH2:18][CH:17]([F:19])[CH2:16][N:15]2C(OC(C)(C)C)=O)=[O:13])[CH2:11][CH2:10][CH2:9]1>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:12]([C@@H:14]2[CH2:18][CH:17]([F:19])[CH2:16][NH:15]2)=[O:13])[CH2:11][CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67429147tert-butyl(2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidine-1-carboxylate

생성물 1

HCID 67428608(2S)-2-(azetidin-1-ylcarbonyl)-4-fluoropyrrolidine trifluoroacetate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

10 mL of trifluoroacetic acid was added under ice cooling to a 30 mL chloroform solution of 2.20 g of the compound obtained in step 7-2, after which the reaction mixture was stirred for 2 hours at room temperature. After this, the reaction mixture was concentrated under reduced pressure to obtain 3.82 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.

후처리

  1. concentrationAfter this, the reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f2ceda13e2484980918cc2ab2eda90e7
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528124B2

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