Trifluoroacetic acid → 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester

HRID 49048

반응식

HRID 49048 반응식
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])=[CH:10][CH:9]=2)=[O:5])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 695874395-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester

생성물 1

HCID 695866655-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester수율 101.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 5-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester (2 g, 6 mmol) and trifluoroacetic acid (8 mL) in dichloromethane (8 mL) was stirred at room temperature for 2 hours. The reaction was concentrated to give 1.6 g (97%) of 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester as a light brown solid.

후처리

  1. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-97e0e3d6a9364f4f8edc82a1239805fa
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706709B2

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