[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol → 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde

HRID 49054

반응식

HRID 49054 반응식
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([CH2:16][OH:17])=[CH:10]2)[CH3:2]>ClCCl.[O-2].[Mn+2]>[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11]([CH:16]=[O:17])=[CH:10]2)[CH3:19]

참가 물질

4

반응물 1

HCID 22042151[5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol

생성물 1

HCID 220421145-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde수율 86.1%

시약·촉매·용매 2

HCID 160959Manganese oxide촉매HCID 6344Dichloromethane용매

실험 절차

Manganese oxide (3.75 g, 43.1 mmol) was added portionwise to [5-(3-diethylamino-propyl)-1H-indol-2-yl]-methanol (660 mg, 2.53 mmol) dissolved in dichloromethane (68 mL) under nitrogen at room temperature. The precipitate was filtered through celite, washing with hot dichloromethane. The filtrate was concentrated to give 563 mg (83%) of 5-(3-diethylamino-propyl)-1H-indole-2-carbaldehyde as a waxy brown solid.

후처리

  1. filtrationThe precipitate was filtered through celite
  2. washwashing with hot dichloromethane
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-d60fafba983a46b6afe1da41a9ce5d74
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706709B2

연결된 노트

불러오는 중…