HCID 67376231, 화합물 → HCID 86608784, 화합물

HRID 490923노트

반응식

HRID 490923 반응식
[CH2:1]([O:3][C:4](=[O:24])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])=[CH:9][CH:8]=1)=[CH2:6])[CH3:2].[C:25]([OH:28])(=[S:27])[CH3:26]>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])=[CH:9][CH:8]=1)[CH2:6][S:27][C:25](=[O:28])[CH3:26])[CH3:2]

참가 물질

4

반응물 2

HCID 67376231HCID 67376231, 화합물HCID 178418634HCID 178418634, 화합물

생성물 1

HCID 86608784HCID 86608784, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of 2-(4-(benzyloxycarbonylamino)phenyl)prop-2-enoic acid ethyl ester (2.2 g, 7.55 mmol) and thioacetic acid (5 mL) in 10 mL of chloroform was heated for 18 hours. The reaction mixture was evaporated in vacuo and purified by flash chromatography through silica gel (5/1 hexanes/ethyl acetate) to afford 2-(4-(benzyloxycarbonylamino)phenyl)-3-(acetylthio)propanoic acid ethyl ester, 0.22 g (8%) as an oil.

후처리

  1. customThe reaction mixture was evaporated in vacuo
  2. custompurified by flash chromatography through silica gel (5/1 hexanes/ethyl acetate)

출처 및 근거

ORD 기록
ord-05734a6f77864d0f8d0772c1467282b5
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528173B2

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