Acetyl chloride → 2'-Iodoacetanilide

HRID 491027노트

반응식

HRID 491027 반응식
[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9](Cl)(=[O:11])[CH3:10]>N1C=CC=CC=1.Cl>[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:9](=[O:11])[CH3:10]

참가 물질

5

반응물 2

HCID 6367Acetyl chlorideHCID 119952-Iodoaniline

생성물 1

HCID 1405592'-Iodoacetanilide

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 1049Pyridine용매

반응 조건

온도
0 °C

실험 절차

2-Iodoaniline (1.00 g, 4.56 mmol) was dissolved in pyridine (5 mL) and cooled to 0° C. After acetyl chloride (314 μL, 5.94 mmol) was added, the reaction was stirred at 0° C. for 1 hour and then at room temperature for 2 hours. The reaction was diluted with 1 N HCl and extracted with ether. The organic layer was dried (MgSO4) and concentrated to give the desired acetamide (assumed quantitative), which was used in the next reaction without further purification.

후처리

  1. waitat room temperature for 2 hours
  2. extractionextracted with ether
  3. dry with materialThe organic layer was dried (MgSO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b315f9eac74f422d83fa6252ec00be08
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528262B2

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