o-Xylyl bromide → Diisopropyl 2-methylbenzylphosphonate

반응식

[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[P:10]([O:19]C(C)C)([O:15][CH:16]([CH3:18])[CH3:17])[O:11][CH:12]([CH3:14])[CH3:13]>>[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][P:10](=[O:19])([O:15][CH:16]([CH3:18])[CH3:17])[O:11][CH:12]([CH3:14])[CH3:13]

참가 물질

반응물 2

HCID 6992o-Xylyl bromide

HCID 8304Triisopropyl phosphite

생성물 1

HCID 15166402Diisopropyl 2-methylbenzylphosphonate

실험 절차

34.5 g (0.19 mol) of 2-methylbenzyl bromide and 39 g (0.19 mol) of triisopropyl phosphite were heated at 150° C. for 2 hours. During this procedure, i-propyl bromide distilled off. The product was distilled through a 30 cm Vigreux column.

후처리

distillationDuring this procedure, i-propyl bromide distilled off
distillationThe product was distilled through a 30 cm Vigreux column

출처 및 근거

ORD 기록: ord-9bbd528effc4400bb7abc75186c3da13
출처 데이터셋: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05242908

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