Bromine → 4-Bromo-2-ethyl-6-methylphenol

HRID 491128노트

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HRID 491128 반응식
[Br:1]Br.[CH2:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[C:6]=1[OH:12])[CH3:4].OS([O-])=O.[Na+]>C(Cl)(Cl)Cl>[Br:1][C:9]1[CH:8]=[C:7]([CH3:11])[C:6]([OH:12])=[C:5]([CH2:3][CH3:4])[CH:10]=1

참가 물질

5

반응물 3

HCID 24408BromineHCID 5193332-Ethyl-6-methylphenolHCID 23665763Sodium Bisulfite

생성물 1

HCID 220068384-Bromo-2-ethyl-6-methylphenol

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

At RT a solution of 12.7 mL (247 mmol) bromine in 10 mL chloroform was added dropwise to a solution of 33.6 g (247 mmol) 2-ethyl-6-methyl-phenol in 350 mL chloroform and the mixture was stirred for 2 h. The reaction mixture was combined with an aqueous NaHSO3 solution and stirred for 20 min. The phases were separated and the organic phase was washed with saturated NaCl solution, dried over Na2SO4 and evaporated down i.vac. Column chromatography (silica gel, Cyc/EtOAc 9:1) yielded the product.

후처리

  1. stirringstirred for 20 min
  2. customThe phases were separated
  3. washthe organic phase was washed with saturated NaCl solution
  4. dry with materialdried over Na2SO4
  5. customevaporated down i.vac
  6. customColumn chromatography (silica gel, Cyc/EtOAc 9:1) yielded the product

출처 및 근거

ORD 기록
ord-8c2ab615cb5a4018a1f6f6954d6db7ce
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07528129B2

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